N.meningitidis is a fastidious, encapsulated, aerobic gram-negative diplococcus. Colonies are positive by the oxidase test and most strains utilize maltose 1, meningococcemia, meningococcal infection, meningococcal meningitis. CHARACTERISTICS: Neisseria meningitidis belongs to the family Neisseriaceae 2. It is a Gram-negative, non-spore forming, non-motile, encapsulated, and non acid-fast diplococci, which appears in kidney bean shape under the microscop Neisseria meningitidis (the meningococcus) is a fastidious Gram-negative diplococcus that colonizes and invades only man. In genetic terms, its closest relative is the gonococcus, Neisseria gonorrhoeae. The entire genetic sequences of a serogroup A and a serogroup B meningococcus have been published Neisseria meningitidis, often referred to as meningococcus, is a Gram-negative bacterium that can cause meningitis and other forms of meningococcal disease such as meningococcemia, a life-threatening sepsis. The bacterium is referred to as a coccus because it is round, and more specifically, a diplococcus because of its tendency to form pairs
Neisseria meningitidis is a significant cause of morbidity and mortality worldwide. Meningococcal isolates have a highly dynamic population structure and can be phenotypically and genetically differentiated into serogroups and clonal complexes . Four species have been reclassified1,2. The clinically important Neisseria species (Neisseria gonorrhoeae, Neisseria meningitidis, Neisseria lactamica and Neisseria cinerea) are relatively easy to identify from the non-pathogenic Neisseria Neisseria meningitidis is immediately reportable on first knowledge or suspicion of the diagnosis due to the potential need for prophylaxis of close contacts within 24 hours of suspected diagnosis (suspicion is normally based on gram stain results - see table on page 4). All other cases of bacterial meningitis ar
Invasive Neisseria meningitidis (N. meningitidis) infection (meningitis, meningococcemia) is associated with high mortality and morbidity worldwide despite the use of proper antibiotics. Fever, bacteremic pneumonia, pericarditis, septic arthritis, urethritis and ear infection are less frequent presentations 1, 2 Neisseria meningitidis - características e epidemiologia da doença meningocócica: Other Titles: Neisseria meningitidis - characteristics and epidemiology of meningococcal disease: Authors: Ramos, Carolina Batista : Orientador: Freitas, Ana Margarida Lopes, Dina Maria Cordeiro Domingues, Sara Margarida dos Santo Neisseria meningitidis (NM) is an important cause of bacterial meningitis and sepsis worldwide. The spectrum of human-meningococcal interactions ranges from asymptomatic carriage to fatal infection. Invasive Meningococcal Disease (IMD) mainly comprises two clinically overlapping syndromes: septicæmia and meningitis
The Neisseria meningitidis organisms are gram negative, aerobic diplococcic that can attach to the surface of mucosal cells of the nasopharynx. Colonization may be transient, intermittent, or long-term, and the prevalence may increase in the presence of conditions such as concomitant upper respiratory infection, crowded living conditions, and. Neisseria meningitidis exists in the nasopharynx of about 5-10% of the population and rarely causes serious disease. Severe meningococcal disease can occur when the bacterium enters normally sterile areas of the body, penetrating through the mucous membranes of the nose and throat. While N. meningitidis can cause infection in the blood or lungs. . Of the 11 species that colonize humans, only two are pathogens, N. meningitidis and N. gonorrhoeae
Neisseria meningitidis, also called N. meningitidis or just meningococcus, is a gram-negative round bacterium that causes meningitis in humans, as well as life-threatening conditions like sepsis and disseminated intravascular coagulation.. Now, N. meningitidis has a thin peptidoglycan layer, so it doesn't retain the crystal violet dye during Gram staining characteristics of invasive disease due to Haemophilus influenzae, Neisseria meningitidis, group A streptococcus (GAS), group B streptococcus (GBS), Streptococcus pneumoniae, and methicillin‐resistant Staphylococcus aureus (MRSA). The entire EIP Network for invasive N Approximately 75 percent of cases with invasive disease have meningitis (typically causing headache, photophobia and neck stiffness). Infants present with less-specific features. Other locations of invasive disease with Neisseria meningitidis are possible though rare, such as orbital cellulitis, septic arthritis, and pericarditis Antibiotic Susceptibility and Characteristics of Neisseria meningitidis Isolates from the African Meningitis Belt, 2000 to 2006: Phenotypic and Genotypic Perspectives Sara Thulin Hedberg , 1, * Hans Fredlund , 1 Pierre Nicolas , 2 Dominique A. Caugant , 3 Per Olcén , 1 and Magnus Unemo Isolation of Neisseria meningitidis. To isolate N. meningitidis, cultures are taken from the nasopharynx, blood, cerebrospinal fluid, and skin lesions. Typically cultures are done on an enriched, non-selective medium such as blood agar or chocolate agar grown in 3-7% carbon dioxide. MTM Chocolate agar is also sometimes used for isolation
2.1 µg/mL or greater: Antibody to Neisseria meningitidis detected. Suggestive of protection. Responder status is determined according to the ratio of the one month post-vaccination concentration to pre-vaccination concentration of IgG antibodies to N. meningitidis (Types A, C, Y, and W-135) as follows: 1 meningitidis serogroups W135 and X 5,6,7,8,9. Outbreaks due to Neisseria meningitidis serogroup C (NmC) have also occurred but were smaller and less frequent than NmA outbreaks 4. The last NmC outbreak in this region occurred in 1979 in Burkina Faso with 539 cases reported (attack rate (AR) 517/100,000) 10. Outbreaks cause The 2,272,351-base pair genome of Neisseria meningitidis strain MC58 (serogroup B), a causative agent of meningitis and septicemia, contains 2158 predicted coding regions, 1158 (53.7%) of which were assigned a biological role. Three major islands of horizontal DNA transfer were identified; two of these contain genes encoding proteins involved in pathogenicity, and the third island contains. Objective Describe the phenotypical and genotypical characteristics of Neisseria meningitidis isolates from cases of meningococcal disease in Paraguay between 1996 and 2015. Methods Conventional microbiological methods and molecular techniques were used to study 114 isolates of N. meningitidis and 12 clinical samples without isolation (confirmed by polymerase chain reaction), provided by.
Limitations: Correct interpretation of the serologic tests depends on culture purity and morphological characteristics and biochemical reactions consistent with Neisseria meningitidis. Serologic methods alone cannot identify the test specimen as Neisseria meningitidis. Excessive heat from external sources such as light source, flame, etc. may. Over the period 1995-2012, the incidence of invasive meningococcal disease (IMD) caused by Neisseria meningitidis serogroup Y (NmY) increased significantly in Sweden. This is mainly due to the emergence of a predominant cluster named strain type YI subtype 1, belonging to the ST-23 clonal complex (cc) Phenotypic and genotypic characteristics of Neisseria meningitidis disease-causing strains in Argentina, 2010. PLoS One. 8 , e58065 (2013). ADS CAS Article PubMed PubMed Central Google Schola
Abstract. Background: Since 2010, there has been an increase in serogroup W Neisseria meningitidis (MenW) disease in many countries due to an emerging sequence type-11 clonal complex (ST-11 CC). In 2016, a small increase in MenW disease due to the ST-11 CC was documented in Ontario, Canada. Objective: To examine the trends in MenW disease in Canada and to assess whether there have been changes. Neisseria meningitidis is an obligate human commensal bacterium that frequently colonises the upper respiratory tract. Person-to-person transmission occurs via direct contact or through dispersion of respiratory droplets from a carrier of the bacteria, and can lead to invasive meningococcal disease. Rare sporadic cases of meningococcal urogenital and anorectal infections, including urethritis.
Label: MENQUADFI- neisseria meningitidis group a capsular polysaccharide tetanus toxoid conjugate antigen, neisseria meningitidis group c capsular polysaccharide tetanus toxoid conjugate antigen, neisseria meningitidis group y capsular polysaccharide tetanus toxoid conjugate antigen, and neisseria meningitidis group w-135 capsular polysaccharide tetanus toxoid conjugate antigen injection, solutio Invasive Meningococcal Disease (IMD) is a critical disease caused by Neisseria meningitidis.In Japan, IMD was listed as a notifiable disease in April 2013. Approximately 60 cases were reported to Japanese national surveillance from April 2013 to December 2014 .N. meningitidis causing IMD usually have the capsule .Encapsulated bacteria are resistant to humoral immunity and have a tendency. Neisseria meningitidis is hosted only by humans and colonizes the nasopharynx; it survives in the human body by reaching an equilibrium with its exclusive host. Indeed, while cases of invasive disease are rare, the number of asymptomatic Neisseria meningitides carriers is far higher. The aim of this paper is to summarize the current knowledge of survival strategies of Neisseria meningitides.
Neisseria meningitidis is a Gram-negative diplococci with 13 distinct serotypes. It inhabits the mucosal surface of nasopharynx and oropharynx .However, about 90% of human disease are caused by serogroup A, B, C, X, Y, and W135 .About 5-10% of healthy people carry N. meningitidis in the nasopharynx and oropharynx and during epidemics, the carrier state rises to 70-80%  TECHNICAL REPORT External quality assurance scheme for Neisseria meningitidis -2014 1 Executive summary Neisseria meningitidis is the major worldwide cause of meningitis and rapidly fatal sepsis in healthy individuals. The risk of meningococcal disease is higher among those with complement deficiencies, asplenia and other underlying conditions characteristics that influence AMP resistance in N. meningitidis (Figure 1) in the order of importance. The inducible effects of AMPs on some of these resistance determinants will also be discussed. 3.1 Lipooligosaccharide (LOS) Lipopolysaccharide (LPS) is the major component of the outer leaflet of the outer membrane of Gram-negative bacteria A MD case was defined as isolation of Neisseria meningitidis, or detection of polysaccharide antigen in a sterile site, or presence of clinical purpura fulminans, or an epidemiological link with a laboratory-confirmed case-patient, between June and August 2008. In 8 out of 16 MD cases studied, serogroup C ST103 complex was identified MenQuadfi is a vaccine used to protect adults and children from the age of 12 months against invasive meningococcal disease caused by four groups of the Neisseria meningitidis bacteria (group A, C, W, and Y). Invasive disease occurs when the bacteria spread through the body causing serious infections such as meningitis (infection of the membranes that surround the brain and spine) and.
Complement C5 inhibitor eculizumab has a great impact on the treatment of patients with paroxysmal nocturnal hemoglobinuria (PNH). However, this treatment success has a major drawback: a substantially increased susceptibility for life-threatening Neisseria meningitidis infections. Therefore, N meningitidis vaccination is strongly advised before initiating complement C5-blocking therapy Isolates of Neisseria species were obtained from eye cultures and Gram stain of conjunctival scrapings disclosed many gram-negative intracellular diplococci. Colony structure and growth characteristics of the organism with subsequent carbohydrate fermentation tests and serotyping were consistent with Neisseria meningitidis Group B The 2751-nucleotide sequence of the gyrA gene is depicted to scale with the use of an isolate from Patient 1 (infected with ciprofloxacin-resistant Neisseria meningitidis) and amplified bacterial. The occurrence of pili has been assessed for 85 strains of Neisseria meningitidis belonging to different serogroups and serotypes, isolated from nasopharyngeal carriers and patients with acute disease. The evolution of piliation on multiple subcultivation has been followed for 16 strains. Almost all the strains were piliated, regardless of their origin, serogroup or serotype. Piliation was.
LOS of Neisseria meningitidis (meningococcus) is an endotoxin that is structurally distinct from LPS of enteric gram-negative bacteria (21, 33). Unlike most enteric LPSs, meningococcal LOS lacks O-antigen and possesses relatively short polysaccharides, only two to five sugar residues, attached to the meningococcal LOS inner core The genus Neisseria, for example, includes the bacteria N. gonorrhoeae, the causative agent of the STI gonorrhea, and N. meningitides, the causative agent of bacterial meningitis. Neisseria are cocci that live on mucosal surfaces of the human body. They are fastidious, or difficult to culture, and they require high levels of moisture, nutrient.
The genetic relatedness of the strains was examined by pulsed-field gel electrophoresis (PFGE), and isolate serogrouping was performed by slide agglutination. Twenty-two (4%) children were carriers of Neisseria meningitidis; seven isolates belonged to serogroup C, and five to serogroup B Lateral Flow Chromatographic Immunoassay (LFCIA) 1. Specificity. This antibody reacts with Neisseria meningitidis serogroups A, B and C and is thought to recognize all antigens. Other serogroups have not been tested. N. meningitidis is a gram-negative bacteria that is the causative agent of meningitis. There are 13 known significant serogroups. Neisseria sicca: a bacterial species found in the mucous membranes of the human respiratory tract A problem isolate resembling Neisseria gonorrhoeae and Neisseria meningitidis is reported. Growth and biochemical characteristics indicated the organism to be N. meningitidis, whereas serological characteristics indicated it to be N. gonorrhoeae. This vaginal isolate may be a genetically transformed gonococcus with the ability to utilize maltose Compared to other families such as Enterobacteriaceae, Vibrionaceae, Streptococcaceae, genomes of bacteria in the Neisseriaceae family have been relatively under-studied. Within this family, Neisseria meningitidis, Neisseria gonorrhoeae and Chromobacterium violaceum are the only species with completely sequenced genomes   
Neisseria: [ ni-se´re-ah ] a genus of gram-negative, aerobic or facultatively anaerobic cocci, which are a part of the normal flora of the oropharynx, nasopharynx, and genitourinary tract. Pathogenic species include N. gonorrhoe´ae, the etiologic agent of gonorrhea ; N. meningi´tidis, a prominent cause of meningitis and the specific agent of. Neisseria meningitidis serogroups A, C, W, and Y. MenQuadfi vaccine is approved for use in individuals 2 years of age and older. (1) MenQuadfi does not prevent N. meningitidis serogroup B disease. DOSAGE AND ADMINISTRATION 0.5 mL dose for intramuscular injection. (2) Primary Vaccination Individuals 2 years of age and older: a single dose Global Neisseria meningitidis Infections Drug Market 2020 by Manufacturers, Type and Application, Forecast to 2025 is the latest report released by MarketsandResearch.bizthat provides helpful insights into all the leading trends of the market.The report presents an in-depth analysis of the key prospects of growth, main growth avenues in the estimation year and existing growth dynamics over the. The genomes of H. influenzae strain Rd and N. meningitidis strains MC58 and Z2491 have been completely sequenced ( 6 - 8). There are many potential simple sequence contingency loci in these genomes, with estimates of 12 for the H. influenzae sequence ( 9, 10) and 26 to 65 for the Neisseria sequences ( 3, 8 ) Neisseria: N. Meningitidis is part of this genus because all are gram negative, many are pathogenic and it is diplococci. Lineage Key: N. Meningitidis is a member of the Beta Proteobacteria. Other members of the Proteobacteria that have similar characteristics to the Beta Proteobacteria are the Alpha, Delta, Gamma, and Epsilon Proteobacteria
Neisseria meningitidis is the causative agent of a life-threatening infection with high mortality and morbidity worldwide. The most common types of this bacterium are serogroups A, B, C, W135, X, and Y. Although in some countries, such as Iran, the meningococcal meningitis has been well monitored and controlled by the use of divalent and quadrivalent vaccines, other fatal infections caused by. Neisseria meningitidis is an aerobic, Gram-negative diplococcus that causes meningococcal diseases such as meningococcemia and bacterial meningitis. Meningitis arises upon inflammation of the meninges, which consists of the membrane that envelops and protects the central nervous system. N. meningitidis is also commonly known as meningococcus. Question: what are the main characteristics of Neisseria meningitidis infection, and what component of the genus Neisseria make them particularly difficult for the host to fight off infection? This question hasn't been solved yet Ask an expert Ask an expert Ask an expert done loading Neisseria meningitidis (the meningococcus) is the causative organism of meningococcal meningitis, because there are 2000 and 3000 cases of meningococcal meningitis per year in the U.S. In about 15% of these individuals, the organism invades the blood and disseminates, leading septicemia and from the there may cross the blood-brain barrier. Growth Characteristics. Neisseria spp. grow best aerobically in an atmosphere containing 5-10% carbon dioxide at a temperature of 89.6-98.6°F (32-37°C) and a pH of 7-7.5. Cell size ranges from 0.6 to 1.5 mm depending upon the species source of the isolate and the age of the culture. Neisseria spp. are fastidious
state oral health program characteristics state oral health program characteristics syphilis syphilis tooth loss tooth loss total total toxic shock syndrome (other than streptococcal) (neisseria meningitidis) meningococcal disease (neisseria meningitidis). Neisseria meningitidis, also known as meningococcus, is found in the oropharynx and nasopharynx of humans. Because the organism survives poorly in the environment, morphological characteristics and biochemical reactions that are consistent with identification of the microorganism as N. meningitidis. 2 Neisseria Meningitidis. Reproduction and Nutrition. The process in which N. Meningitidis reproduces is binary fission. Binary fission is one of the most common ways for bacterial cells to reproduce. The steps of binary fission are as follows: Chromosome attaches to plasma membrane. N. meningitidis is classified into 12 serogroups based on the immunological characteristics of the capsular polysaccharides found at their surface. Within serogroups, different serotypes, subtypes, and immunotypes can be identified based on the antigenic specificity of the major outer membrane (OM) 1 proteins and LPS ().Approximately 90% of all meningococcal diseases worldwide are caused by. 9. Flowchart for laboratory identification ofNeisseria meningitidis 31 10. Kovac's oxidase test: a positive reaction on filter paper 33 11. Positive and negative agglutination reactions on a slide: grouping 35 antisera and saline control with Neisseria meningitidis 12. Cystine trypticase agar sugar reactions for acid production from 3
Molecular data on a limited number of chromosomal loci have shown that the population of Neisseria meningitidis ( Nm ), a deadly human pathogen, is structured in distinct lineages. Given that the Nm population undergoes substantial recombination, the mechanisms resulting in the evolution of these lineages, their persistence in time, and the implications for the pathogenicity of the bacterium. Neisseria meningitidis The bacterium Neisseria meningitidis, the meningococcus, is identical in its staining and morphological characteristics to Neisseria gonorrhoeae. However, at the ultrastructural level, N. meningitidis has a prominent antiphagocytic polysaccharide capsule. N Neisseria meningitidis autoaggregation is an important step during attachment to human cells. Aggregation is mediated by type IV pili and can be modulated by accessory pilus proteins, such as PilX, and posttranslational modifications of the major pilus subunit PilE. The mechanisms underlying the regulation of aggregation remain poorly characterized. Polynucleotide phosphorylase (PNPase) is a 3. Neisseria meningitidis is a Gram-negative diplococcal bacterium that can harmlessly inhabit the human nasopharynx. For reasons not completely understood, meningococci can invade the mucous membrane and gain access to the bloodstream, leading to meningitis, severe sepsis, or localised infections involving the joints or heart. Invasive meningococcal disease (IMD) can progress rapidly in.
Neisseria meningitidis, the causative agent of epidemic meningitis, is a significant global public health burden, with 1.2 million cases each year and an estimated fatality rate of 10 per cent.The disease is prevalent in Africa and Asia due to cyclical pandemics occurring on these continents every eight to 10 years Bacticard Neisseria and Neisseria Preformed Enzyme Test (PET). This is of particular concern because global transmission of PIP-negative gonococcal strains has previously been described . b The porA gene in the N. gonorrhoeae strain showed 94% sequence identity with the gene in the genome-sequenced N. meningitidis reference strain MC58  Strains of Neisseria meningitidis isolated from patients and asymptomatic individuals who had been in contact with patients were investigated using four typing methods with the aim of identifying any heterogeneity and/or homogeneity among the strains. In 1993, a dramatic change in the incidence and severity of invasive meningococcal disease in the Czech Republic occurred as a consequence of. Neisseria meningitidis, IgG, Vaccine Response, MAID - This assay measures serum IgG antibodies recognizing polysaccharide antigens from the four Neisseria meningitidis serogroups included in the licensed meningococcal vaccine. The meningococcal vaccine response is best evaluated by testing pre-vaccination and post-vaccination samples in parallel IN.gov | The Official Website of the State of Indian
Neisseria is a genus of bacteria commonly present on mucosal surfaces. Several species exist, but only 2 are pathogenic to humans: N. gonorrhoeae and N. meningitidis.Neisseria species are non-motile, gram-negative diplococci most commonly isolated on modified Thayer-Martin (MTM) agar. These pathogens have many virulence factors, including fimbriae, lipooligosaccharide envelope proteins, a. 【Abstract】Objective To understand the epidemiological characteristics of meningococcal meningitis and analyze the changing trend of serogroups of Neisseria meningitidis in Anhui province.Methods Descriptive epidemiological method was conducted by using the data from China information system for disease control and prevention and laboratory during 2004-2017
Up-to-date information regarding the antibiotic susceptibility of Neisseria meningitidis strains from African countries is highly limited. Our aim was to comprehensively describe the antibiotic susceptibilities of a selection of N. meningitidis isolates recovered between 2000 and 2006 from 18 African countries, mainly those within the meningitis belt. Susceptibilities to 11 antibiotics were. Bacterial co-infection in the ongoing pandemic of COVID-19 is associated with poor outcomes but remains little understood. A 22-year-old woman presented with a 3-week history of fever, headache, neck stiffness, rigours and confusion. She was noted to have a purpuric rash over her hands and feet. Cerebrospinal fluid bacterial PCR was positive for Neisseria meningitidis Neisseria meningitidis is a capsulated gram-negative bacterium, which is a major cause of meningitis and sepsis, two devastating diseases that can kill children and young adults within hours despite the availability of effective antibiotics. The bacterium is found only in humans and is classified into 13 serogroups on the basis of the chemical composition of the capsular polysaccharides DISCUSSION. Neisseria meningitidis, Gram-negative diplococcus, was described in 1887 as major cause of meningitis and meningococcal bacteremia in all ages.The dissemination occurs through the nasopharynx with hematogenous spread to the meninges or other organs. It is not part of the normal gastrointestinal flora and isolated only in rectal secretions in combination with sexual transmission
Neisseria. General Characteristics of Neisseria spp. Aerobic Gram-negative cocci often arranged in pairs (diplococci) with adjacent sides flattened (like coffe beans) Oxidase positive Most catalase positive Nonmotile Acid from oxidation of carbohydrates, not from fermentation Important Human Pathogens Neisseria gonorrhoeae Neisseria meningitidis Neisseria meningitidis characteristics symptoms. petechial rash found in bacteremia. Neisseria meningitidis clinical manifestations. meningococcemia, fulminant disease, arthritis. Fulminant disease. hemorrhage in the adrenal glands-Waterhouse-Friderichsen syndrome kids aged 6mos to 2 years. miltary, freshmen. Which contains a capsule: N. meningitidis or N. gonorrhoae. N. meningititdis - defines serological groups. the endotoxin of neisseria is __. LOS. __ help neisseria adhere to mucosal surfaces. pili. outer membrane proteins of neisseria include Introduction South Australia (SA) has the highest notification rate of invasive meningococcal disease in Australia with the majority of cases due to serogroup B. Neisseria meningitidis is carried in the pharynx, with adolescents having the highest rates of carriage. A vaccine designed to offer protection against serogroup B (4CMenB) is licensed in Australia
Complement-mediated bactericidal activity has long been regarded as the serological correlate of protective immunity against Neisseria meningitidis. This was affirmed in 2005 at a WHO-sponsored meningococcal serology standardization workshop. The assay currently employed by most laboratories involves determining surviving bacterial colony counts on agar as a readout which is labor-intensive. Nimenrix is a vaccine used to protect adults, adolescents and children from the age of 6 weeks against invasive meningococcal disease caused by four groups of the bacterium Neisseria meningitidis (group A, C, W-135, and Y) Neisseria meningitidis is one of the main agents of bacterial meningitis, causing substantial morbidity and mortality worldwide. However, most of the time N. meningitidis is carried as a commensal not associated with invasive disease. The genomic basis of the difference between disease-associated and carried isolates of N. meningitidis may provide critical insight into mechanisms of virulence. The best studied members of the genus Neisseria are the human pathogenic species Neisseria gonorrhoeae (Ngo) and Neisseria meningitidis (Nme). Ngo is a human specific pathogen estimated to cause >800 000 cases of gonorrhea in the USA each year (Centers for Disease Control and Prevention 2015 )