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Desmoplastic nevus treatment

Desmoplastic (sclerotic) nevus: an underrecognized entity

  1. antly spindle-shaped nevus cells within a fibrotic stroma, can be confused with fibrous lesions and other melanocytic proliferations, including desmoplastic melanoma. We compared the histologic and immunohistochemical features of 16 desmoplastic nevi, nine.
  2. Over the years, the nevus became pruriginous, light brown, bumpy, and hard. Histology revealed nevus cells interspersed with dense fibrosclerotic collagen bundles. There are few reported cases of large congenital melanocytic nevus with this evolution, so-called desmoplastic hypopigmented hairless nevus
  3. antly spindle-shaped naevus cells within a fibrotic stroma. It is regarded by some as a type of Spitz naevus, by others as a distinct entity
  4. Surgical excision with a rim of normal tissue around the entire tumor is the treatment of choice for DM. Conventional prognostic parameters (tumor thickness, ulceration status, tumor mitotic area) also apply to DM and should be reported. 23 Further classification into pure versus mixed DM is relevant for prognosis and clinical management

Surgical Care Excision of lesions suspected of being Spitz nevi with histopathologic evaluation of the margins of the specimen is indicated. [ 30, 31] Sentinel lymph node biopsy is not justified.. A dysplastic nevus is a type of mole that looks different from a common mole. (Some doctors use the term atypical mole to refer to a dysplastic nevus.) A dysplastic nevus may be bigger than a common mole, and its color, surface, and border may be different. It is usually more than 5 millimeters wide (1, 3). A dysplastic nevus can have a. Spitz (spindle and epithelioid cell) nevus with dense eosinophilic stroma Other Spitz nevus features present (Kamino bodies, etc.) Uncertain relationship to desmoplastic (sclerotic) nevus (Am J Dermatopathol 2011;33:35 The initial treatment of a desmoplastic melanoma is surgical excision. For pure desmoplastic melanoma, a 2 cm margin of normal tissue may be recommended, whatever its thickness. For mixed desmoplastic melanoma, margins follow guidelines for other forms of invasive melanoma (1-2 cm, depending on Breslow thickness) It's a severe dysplastic/atypical melanocytic nevus. Upon my research, this doesn't seem like that big of a deal, and it seems it's pretty damn rare that any atypical nevus will, itself, turn into melanoma. Especially for me, since this is my only one. So I'm struggling to understand how that could translate to almost cancer

Melanoytic naevi | Primary Care Dermatology Society | UK

A Spitz naevus (or Spitz's nevus) is an uncommon type of mole ( melanocytic naevus). A Spitz naevus is a benign skin tumour. However, it may resemble a melanoma clinically and microscopically, so Spitz naevi are often excised as a precaution. Spitz naevi. Classic Spitz naevus Radiation therapy uses radiation to kill the cancer cells. External radiation therapy comes from a machine that aims radiation at the tumors. For internal radiation therapy, seeds, ribbons, or capsules that contain a radiation source are placed in your body, in or near the tumor. Do desmoplastic small round cell tumors run in families 1. J Am Acad Dermatol. 2011 Aug;65(2):e57-8. doi: 10.1016/j.jaad.2010.12.029. Desmoplastic cellular neurothekeoma mimicking a desmoplastic melanocytic tumor Desmoplastic trichoepithelioma treatment True desmoplastic trichoepithelioma is a benign tumor with no malignant potential, so there is no need to remove them. However, it is best to keep the lesion under observation in case the diagnosis is incorrect, as basal cell carcinoma may look very similar

Desmoplastic hypopigmented hairless nevus: a variant with

Desmoplastic naevus - PCD

• In ten cases of neurotropic melanoma, patients presented with nodules composed of amelanotic, deeply infiltrating neuroid fascicles. Only four cases were clinically suggestive of melanoma. In eight of the tumors, a precursor lesion was found histologically and provided a major clue to the.. A 67-year-old man with CLL presents with 3 month h/o 3 cm dense dermal growing scalp mass. Incisional biopsy showed spindle cell melanoma. The tumor was resected with a 2 cm margin. Final pathology showed malignant melanoma—spindle cell / desmoplastic type. Additional 1.2 cm margin was resected for wide clearance creating a 10 x Honore C, et al. Abdominal desmoplastic small round cell tumor: Multimodal treatment combining chemotherapy, surgery and radiotherapy is the best option. Annals of Surgical Oncology. 2015;22:1073. Jordan AH, et al. Management of desmoplastic small round-cell tumors in children and young adults Mérot, Y. and Frenk, E. (1989) Spitz nevus (large spindle and/or epithelioid cell nevus). Age-related involvement of the suprabasal epidermis. Virchows Arch. A (Pathol. Anat)., 415, 97-101. CrossRef Google Schola

An excisional biopsy is preferred wherever possible. 1, 3, 5 Lesser specimens (punch, shave, curettings) may be distorted and may not permit adequate assessment of the vital parameters needed by the clinician for definitive treatment (eg, Breslow thickness, mitotic rate). 13 Smaller specimens also may not be representative of the lesion and usually lack the edges and bases of the lesions needed to assist diagnostic interpretation. 3, Lentigo maligna/lentigo maligna melanoma (LM/LMM) affects chronically sun-damaged skin of the head and neck with a slow radial growth phase. It is characterised by predominantly lentiginous proliferation of small, but atypical melanocytes with occasional upward scatter in an atrophic epidermis. It is not uncommon for pathologists to receive partial or scouting biopsies to assess for LM Objective Desmoplastic melanoma (DM) is a rare variant of invasive malignancy of the skin pigmented cells. We present a comprehensive study reporting on US demographics, disease characteristics, and survival, to contribute to the current knowledge and raise awareness of this rare disease. Materials and methods The demographics of DM patients diagnosed from January 1, 2004, to December 31, 2015. In contrast to DM, desmoplastic nevus appears to be associated with younger age and development on non-sun-exposed areas. Thus, patient age and anatomic location seem to be important criteria in the differential diagnosis between benign and malignant desmoplastic neoplasia. 1

The sections demonstrate a shave biopsy in which there is compound melanocytic proliferation, consisting of junctional component exhibiting features of dysplastic nevus while the dermal component shows epithelioid and pigmented morphology with prominent nucleoli and moderate cytologic atypia. No definitive mitotic figure identified While the 1,064 nm QS Nd:YAG laser has demonstrated efficacy in treating melasma and nevus of Ota, to our knowledge no studies have addressed its efficacy for solar lentigines . We report a case of a desmoplastic melanoma (DM) arising after 1,064-nm QS Nd:YAG laser therapy for a suspected solar lentigo of the inferior eyelid Desmoplastic small round cell tumors, or DSRCT, are tumors that grow in the abdomen and pelvic area of the body. Desmoplastic small round cell tumors are a type of soft tissue sarcoma, which is a type of cancer that forms in the connective tissue of the body. Connective tissues include fat, muscles, tendons, lymph and blood vessels, and nerves

What other growths may be mistaken for desmoplastic melanomasand vice versa? Quite a few, actually, including some that are benign (dermatofibroma, blue nevus) and others that are either locally aggressive (atypical fibroxanthoma, dermatofibrosarcoma protuberans) or overtly malignant (spindle cell sarcoma, cutaneous leiomyosarcoma) sclerosing (desmoplastic) blue nevus; Diagnosis. The only treatment is to remove the mole surgically, although this is not usually necessary. In rare cases, a blue nevus may develop into. Another variant, desmoplastic blue nevus, histologically shows exaggerated dermal fibrosis and may be confused with desmoplastic melanoma. Additionally, blue nevus-like melanoma must carefully be distinguished from blue nevi, especially the cellular subtype, to avoid delayed diagnosis and treatment, as the two frequently get mistaken for one. If the nevi do recover a typical appearance within a month, surgical excision should be performed. 17,58 Uncommon variants Desmoplastic nevusClinical features Desmoplastic (sclerotic) nevus is an infrequently reported, poorly characterized, benign melanocytic proliferation, with only few case series published to date. 60 Clinically, DN is. Desmoplastic Spitz's nevus = وحمة سبيتز المكونة للالتصاقات Complete excision with a clear margin of normal skin is generally sufficient treatment for Spitz nevi. Given the difficulty of confidently excluding the possibility of melanoma in certain cases,.

Malignant neoplasm associated with nevus sebaceous of Jadassohn. J Am Acad Dermatol. 1979; 1:545-56. Xin H, Matt D, Qin JZ, Burg G, Böni R. The Sebaceous Nevus: A Nevus with Deletions of the PTCH Gene. Cancer Res.1999; 59: 1834-6. Schweiger E, Spann CT, Weinberg JM, Ross B. A Case of Desmoplastic Trichilemmoma of the Lip Treated with Mohs Surgery Within this group, desmoplastic melanoma developed in 5 patients. For each diagnosed melanoma, histological characteristics, treatment, and outcomes were evaluated. Results. Of the 5 patients described in this study, 2 were males and 3 females. The average age was 62.4 years ranging from 56 to 68 years

Abstract The desmoplastic melanocytic nevus is an uncommon variant that easily may be confused with a fibrohistiocytic neoplasm or a desmoplastic melanoma. It is believed that the following report describes the first known example of a desmoplastic melanocytic nevus arising in the oral mucosa Desmoplastic trichilemmoma (DT) is a rare benign histologic variant of trichilemmoma, a benign growth of the pilosebaceous follicle's outer sheath. Headington and French first described trichilemmoma in 1962. The presence of irregular cords and epithelial cell nests in a prominent densely sclerotic collagenous stroma in its center differentiate DT, which Hunt and colleagues described in 1990. Spitzoid melanoma is a type of skin cancer. It begins when the melanocytes in the skin grow out of control and form tumors. Melanocytes are the cells responsible for making melanin, the pigment that determines the color of the skin. Spitzoid melanoma looks very much like an uncommon but benign skin mole called a Spitz nevus, both to the naked. Desmoplastic astrocytoma: new insights into its clinical profile, diagnosis, and treatment. Rojas-Medina LM, Carrasco-Moro R, Rivero-Garvía M, Esteban-Fernández L, Rivas-Infante E, Márquez-Rivas J. Childs Nerv Syst, 32(9):1577-1585, 01 Sep 2016 Cited by: 1 article | PMID: 27624454. Revie

Desmoplastic Melanoma - an overview ScienceDirect Topic

Desmoplastic melanoma (DM) is a rare morphological subtype of melanoma that remains uncharacterized. The aim of the present study was to investigate the incidence of DM, its general demographics, clinicopathological features and disease‑specific prognostic factors. DM cases were sampled from the Surveillance, Epidemiology and End Results (SEER) program from between 1973 and 2017 Desmoplastic neuroepithelial tumor of infancy in the nevus sebaceus syndrome: report of a unique constellation and review of the literature. Kopniczky Z, Kobor J, Maraz A, Vajtai I. Department of Neurosurgery, University of Szeged Health Sciences Center, Hungary Aggressive treatment is usually not needed, but monitoring for signs of relapse, as well as subsequent melanomas, is recommended. [3] A rare variant is the desmoplastic Spitz nevus in which the proliferating large epithelioid and/or fusiform melanocytes are embedded in a desmoplastic stroma with thick eosinophilic collagen bundles. [20

Key Terms Spitz Nevus Atypical Spitz nevus Atypical Spitzoid tumor Desmoplastic Spitz nevi Dermatofibroma Cutaneous fibrous histiocytoma Bednar tumor Papular and nodular neoplasms without scale comprise many important and potentially deadly tumors of the skin. Although this group of lesions is usually without scale, it is important to recognize that any lesion with significant traum Other common secondary neoplasms include tricholemmoma, sebaceous adenoma, desmoplastic tricholemmoma, apocrine adenoma, and poroma. Epidemiology. Approximately 0.3% of newborns are affected by nevus sebaceus, and the incidence is equal between male and female patients. The disorder affects all races and ethnicities Malignant blue nevus is a malignant cell blue nevus and is characterized by an aggressive course, although cases with late metastasis are described. Sometimes there is against the background of the nevus Ogs. It is observed mainly in middle-aged and elderly people, mainly on the face and scalp, chest, buttocks

Nevoid basal cell carcinoma syndrome (NBCCS), also known as Gorlin syndrome or fifth phacomatosis, 1, 2 is an autosomal dominant multisystem disorder that affects 1 in 60,000 individuals. 3 The well defined diagnostic criteria include multiple developmental anomalies and a predisposition to the development of early-onset neoplasms. 4, 5 Developmental manifestations include characteristic. zy DESMOPLASTIC MALIGNANT MELANOMA (A RARE VARIANT OF SPINDLE CELL MELANOMA) JOHN MD, RAFFAELE CONLEY, ORK, LATTES,MD, AND WILLIAM MD This is a detailed report of seven cases presenting a peculiar sequence of events which, starting from inconspicuous superficial melanotic lesions, generally lo- cated in the head and neck regions leads to the production of bulky subcutan- zyx eous tumefactions Desmoplastic melanoma: is a rare malignant melanoma marked by non-pigmented lesions on sun-exposed areas of the body Junctional nevus: Smooth, hairless, light to dark brown mole. Can be slightly elevated, usually multiple and can occur on any part of the body Treatment repeats every 42 days for 2 courses in the absence of disease progression or unacceptable toxicity. After completion of study treatment, patients are followed up at 3, 6, 9, 12, 16, 20, 24, 36, 48, 60, and 72 months The blue nevus and variants represent a congenital or acquired, dermal collection of pigment producing melanocytes. The prevalence of blue nevus is as high as 3 percent to 5 percent in the Asian population. Sclerosing (desmoplastic) blue nevus represents an uncommon variant of common blue nevus

Spitz Nevus Treatment & Management: Surgical Care

Spitz nevus: Pictures, diagnosis, and treatment

Desmoplastic trichoepithelioma. Desmoplastic trichoepithelioma or sclerosing epithelial hamartoma. A desmoplastic trichoepithelioma is a cutaneous condition characterized by a solitary, firm skin lesion on the face Introduction. Desmoplastic melanoma (DM) is first described by Conley et al in 1971 as a cutaneous tumor exhibiting similar clinical and histological patterns as invasive fibrous tumors, but with distinct morphological characteristics. 1 At present, DM is considered to be a variant of spindle cell melanoma, accounting for less than 4% of all types of melanoma Desmoplastic trichilemmomas can also occur within nevus sebaceous. As trichilemmoma is a benign growth, no treatment is needed. However, if further removal is desired, electrodesiccation, cryotherapy, shave removal, or excision are treatment options

Common Moles, Dysplastic Nevi, and Risk of Melanoma

  1. ant multisystem disorder that affects 1 in 60,000 individuals. 3 The well defined diagnostic criteria include multiple developmental anomalies and a predisposition to the development of early‐onset neoplasms. 4, 5 Developmental manifestations include characteristic.
  2. g a desmoplastic malignant melanoma combined with lentigo maligna
  3. Aggressive treatment is usually not needed, [Desmoplastic Spitz nevus: a histopathological review and comparison with desmoplastic melanoma]. Ann Dermatol Venereol. 2009 Oct. 136(10):689-95

Other Spitz nevus variants (angiomatoid, desmoplastic

  1. Many are melanomas in situ, and many more are only superficially invasive with little chance of metastases. The risk and staging is stratified based on the depth of invasion. Less than 0.8 mm depth of invasion, 1-2 mm, 2-4 mm, and more than 4 mm. In addition, the presence of ulceration worsens the stage and prognosis
  2. Desmoplastic melanoma is regarded as a locally aggressive melanoma subtype with local recurrence rates as high as 40-60%. 3-6 For this reason, adjuvant radiotherapy has been advocated by some for local control. 6, 7 A Phase II trial to evaluate the benefit of adjuvant radiation has been initiated by the North Central Cancer Treatment Group.
  3. In an atypical compound nevus, the epidermal component extends beyond the lateral border of the dermal nevus cells Histology of malignant melanoma, desmoplastic variant. S100+, HMB45 negative. Treatment for nevus of Ota. Very low risk; choroid. What is the risk of nevus of Ota developing into melanoma and if it does, where is most.
  4. Prognosis and Treatment. Actas Dermosifiliogr. 2020 Jan 2. 111 (1 [Desmoplastic Spitz nevus: a histopathological review and comparison with desmoplastic melanoma]. Ann Dermatol Venereol. 2009.
  5. It may also arise from uncommon lesions, such as a congenital mole or spitz nevus. Persistent melanoma. Persistent melanoma is a tumor that regrows after the original tumor was removed. Desmoplastic melanoma and lentigo maligna melanoma are especially likely to become persistent. 1
  6. imal dermal elastosis. He also said that with positive margins, complete re-excision may be prudent. However my dermatologist said that no further treatment was required
  7. The lesional cells are typically fibroblast-like (Figure 7, B) and can be mistaken for a benign spindle cell lesion (eg, scar, neurofibroma, dermatofibroma), a conventional blue nevus, or desmoplastic forms of nevi. 1,2,93-95 The demographics can be helpful in the identification of desmoplastic nevi, as these lesions tend to occur on the.

Desmoplastic melanoma DermNet N

Combined blue nevus; Sclerosing (desmoplastic) blue nevus; Epithelioid nevus. What are the clinical features of blue nevus? The common blue nevus is a solitary, bluish, smooth surfaced macule, papule or plaque. They are generally round or oval in shape. The common blue nevus is usually 0.5-1 cm in diameter Spitz nevus is a variant of melanocytic nevus which is histopathologically defined as large spindle and/or epithelioid cells. Angiomatoid Spitz nevus is a rare histologic variant of desmoplastic Spitz nevus characterized by prominent vasculature. We present a case of angiomatoid Spitz nevus, celluar type, that has not been reported before Desmoplastic nevi do not show elongated fusiform spindle cells (with the exception of desmoplastic Spitz nevi), and such a lesion would warrant consideration of a blue nevus or a desmoplastic melanoma, in addition to other non-melanocytic spindle cell lesions

Persistent Melanocytic Nevus is recurrence of benign melanocytic nevi at the site of its surgical removal. This takes place due to an incomplete removal of the skin lesion. The nevus that recurs is usually a compound mole or an intradermal mole. This skin condition is also known as Recurrent Melanocytic Nevus Primary treatment for skin cancer is often surgery, with radiation therapy as an adjuvant therapy. Radiation kills cancer cells left after the skin cancer was removed. 2 This is recommended for: BCC, SCC, or melanoma that grew into a nerve. 6,8,9. Non-melanoma skin cancer when cancer cells are found on the edges of the sample (positive margins. Desmoplastic neurotropic melanomas are neuroectodermal tumors that usually arise from an intraepidermal melanocytic proliferation but rarely develop de novo in the dermis. Schwannian and perineurial differentiation may account for the desmoplasia and neurotropism encountered in these neoplasms Desmoplastic nevus . 9. Pigmented epithelioid melanocytoma . 10. Animal-type melanoma . 11. Nevoid melanoma . 12. Balloon cell melanoma . 13. Desmoplastic melanoma . Caterina Longo is a dermatologist specializing in the diagnosis and treatment of skin cancers by noninvasive modalities such as dermoscopy and confocal microscopy. She works as.

Almost Cancer - Severely Dysplastic Nevus - Melanoma

The desmoplastic Spitz nevus has an inverted wedge-shaped pattern, manifesting an admixture of spindle cells with delicate elongate nuclei and bizarre ganglion-like cells, the dual population of. However, weekly positivity is seen in desmoplastic sclerotic nevus. d. Melan-A/Mart-1. Melan-A expression was found in 51.4% of desmoplastic melanoma. Melan-A is weakly positive in desmoplastic melanoma, whereas, it is strongly positive in the desmoplastic sclerotic nevus. Prognosis Regional lymph node involvement is reported in 0 t Vein Treatment; Cases Desmoplastic Spitz nevus Pigmented spindle cell nevus Combined nevus with BAP1-inactivated nevus, deep penetrating nevus, Spitz nevus, or pigmented epithelioid melanocytoma components, and atypical variants

Spitz naevus DermNet N

Desmoplastic Spitz nevus is a variant, in which there are small nests and individual melanocytes embedded in fibrotic, hyalinized stroma . Angiomatoid, myxoid, and plexiform among others, are different histologic variants of Spitz nevi. Pigmented spindle cell nevus of Reed is considered by some authors as a variant of Spitz nevus Nevus pilosus is characterized by closely set terminal follicles. Treatment . No therapy is required. Excision can be considered for cosmesis. In the evaluation of a hair follicle nevus or accessory tragus in a small child, parents can be counseled that the relative size of the lesion will diminish with time. The child will grow.

Search Page 1/1: LENTIGO. 4 result found: ICD-10-CM Diagnosis Code L81.4 [convert to ICD-9-CM] Other melanin hyperpigmentation. Lentigo; Lentigo (brown spot on skin); Lentigo solaris (brown spot on skin from sun); Melanosis of vulva; Senile lentigo; Lentigo. ICD-10-CM Diagnosis Code L81.4. Other melanin hyperpigmentation A hypomelanotic blue nevus, an uncommon variant, generally presents clinically as a depigmented papule with focal residual blue-brown pigment. 1. The many faces of blue nevus: A clinicopathologic study. However, to our knowledge, clinical images of a completely amelanotic blue nevus have not been published in the literature

Desmoplastic Small Round Cell Tumors (DSRCT) - National

E-Mail Address. Password. Forgotten Password? Remember M Women 20-40 years old Back > face, extremities History of biopsy or excision, with or without free margins Appear within weeks-months after excision Pigment usually within margins of scar Pigment fades with time Benign or atypical nevi most commonly recur Fig. 11.1 Recurrent melanocytic nevus. Multiple irregularly shaped pigmented streaks are present within the margins of a Desmoplastic melanoma. A flat nodule with bluish-red and brown portion in an elderly male; lesions often are surrounded by a macular portion resembling lentigo maligna

Desmoplastic cellular neurothekeoma mimicking a

Treatment options for basal cell carcinomas are challenging in BCNS due to the sheer number of BCCs which develop. Moh's micrographic surgery, 5% imiquimod, PDT or even vismodegib are all primarily based on sporadic BCCs. The therapy of patients with basal cell nevus syndrome must be individualized to the patient (Lam, Dermatol Surg 2013) Introduction. Nevus sebaceous, also called nevus sebaceous of Jadassohn or organoid nevus, is a benign skin malformation. 1 Considered to be rare, it is responsible for up to 0.2 percent of dermatological appointments. 2 The lesions can be present at birth or appear in early childhood, with similar prevalence in both sexes, and occasionally with a positive familial history Trichoblastoma, syringocystadenoma papilliferum, desmoplastic trichilemmoma and tumor of the follicular infundibulum with signet-ring cells, all arising in nevus sebaceous. J Cutan Pathol 2015 ; 42: 645 - 651

Amelanotic melanoma refers to a rare variant of skin cancer. It begins when the melanocytes in the skin grow out of control and form tumors. Melanocytes are the cells responsible for making melanin, the pigment that determines the color of the skin. Amelanotic melanoma is different from other skin melanomas in that it appears as a pink or red. • DesmoplasIc (Spitz) nevus: p16 NOT helpful (strong in 75% pure DM) • Neurofibroma: fingerprint parern CD34 posi<vity • MPNST: S-100 and Sox-10 usually weak/patchy, BRAF usually nega<ve, loss of H3K27me3 65 Desmoplastic nevus Neurofibroma D spitz nevus (10) 10 Filter by: Remove filter: treatment outcome (10) 10 Filter by: Remove filter: child, preschool (9) 9 Filter by: Remove filter: desmoplastic small round cell tumor - genetics (9) 9 Filter by: Remove filter: development and progression (9) 9 Filter by: Remove filte in nevus sebaceous. desmoplastic trichoepithelioma - what is the treatment? excision for single, skin resurfacing for multiple. what is a trichoblastoma? benign neoplasm of follicular germ cells. what is the treatment for rupture? incision and drainage. epidermal inclusion cyst - what is the treatment for EIC?.

Diagnosis: Desmoplastic melanoma with mixed histology, greater than 7.25 mm thick No evidence of distant spread. The patient has been seen at two centers for discussion of further treatment. Local radiotherapy was recommended at both, although two different protocols were discussed. The patient is undecided if he wants radiotherapy at this time Keratinocyte carcinoma, traditionally referred to as nonmelanoma skin cancer, includes basal cell and cutaneous squamous cell carcinoma and is the most common skin cancer malignancy found in humans

Trichilemmoma Workup: Laboratory Studies, Imaging StudiesThe dysplastic nevus: From historical perspective toPPT - Surgical Treatment of Malignant Melanoma PowerPoint

The spitz nevus: review and update. Lyon VB. Clin Plast Surg. 2010 Jan;37(1):21-33. (REVIEW) PMID 19914455 : Spitz nevus versus spitzoid melanoma: diagnostic difficulties, conceptual controversies. Mooi WJ, Krausz T. Adv Anat Pathol. 2006 Jul;13(4):147-56. PMID 16858148 : Spitz nevus and its histologic simulators. Mooi WJ. Adv Anat Pathol. 2002. The division of Dermatopathology at Weill Cornell Medicine is pleased to announce its new Diagnosis Gallery. The gallery includes outstanding and interesting cases originating from around the world including New York City. Through high-quality illustrations of various lesions, the gallery reflects the diversity of daily practice. They encompass routine cases as well as th Regional melanoma. For cancer that has spread to nearby lymph nodes or nearby areas of the body, the five-year survival rate is 64%. Distant melanoma. For cancer that has spread to remote parts of. Desmoplastic melanoma (DM) has been associated with higher local recurrence rates than other types of cutaneous melanoma. Current controversies regarding locoregional treatment strategies warrant further investigation. Retrospective review of a prospectively maintained melanoma database identified 129 patients with DM out of >12,500 melanoma patients referred for treatment from 1980 to 2003 Summary Dr Sophie Spitz proposed a criterion to distinguish those melanocytic proliferations of childhood that manifested an aggressive biologic behavior from their indolent, but histologically sim..